Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast
Yue Shen, Feng Gao, Yun Wang, Yuerong Wang, Zheng Ju, Jianhui Gong, Jintao Zhang, Zhouqing Luo, Daniel Schindler, Yang Deng, Weichao Ding, Tao Lin, Reem Swidah, Hongcui Zhao, Shuangying Jiang, , Yizhi Cai
The paper constructs a synthetic disomic yeast using SCRaMbLE and a newly synthesized chromosome to study aneuploidy phenotypes, finding that both copy number and specific chromosomal regions affect fitness.
Cell Genomics · Nov 1, 2023Peer-reviewedSynthetic Biology