Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response
Wenxiang Xue, Hongyan Chu, Jiehuang Wang, Yingjie Sun, Xusheng Qiu, Cuiping Song, Lei Tan, Chan Ding, Ying Liao
This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.
PLoS Pathogens · Nov 27, 2024Peer-reviewedMicrobiology