Mapping AAV capsid sequences to functions through function-guided in silico evolution
Binjie Guo, Hanyu Zheng, Xurong Lin, Haohan Jiang, Aisheng Mo, Hongyan Wei, Ru Zhang, Yubin Yuan, Yile Wu, Hengguang Li, Yunshuo Zhang, Zhuoyuan Song, Xuebin Ni, Yan Huang, Bin Yu, , Xuhua Wang
The paper introduces ALICE, a platform that uses function-guided in silico evolution to design AAV capsids with tailored properties, demonstrating improved targeting and tropism in mice.
Cell Press Blue · May 1, 2026Peer-reviewedBioengineering