Author

Haohan Jiang

First Affiliated Hospital Zhejiang University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:contrastive learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Binjie Guo· 2 shared Hanyu Zheng· 2 shared Xuhua WangiD· 2 shared Aisheng Mo· 1 shared Bin YuiD· 1 shared Hengfu YangiD· 1 shared Hengguang LiiD· 1 shared Hongyan Wei· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

Binjie Guo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mapping AAV capsid sequences to functions through function-guided in silico evolution

Binjie Guo, Hanyu Zheng, Xurong Lin, Haohan Jiang, Aisheng Mo, Hongyan Wei, Ru Zhang, Yubin Yuan, Yile Wu, Hengguang Li, Yunshuo Zhang, Zhuoyuan Song, Xuebin Ni, Yan Huang, Bin Yu, , Xuhua Wang

The paper introduces ALICE, a platform that uses function-guided in silico evolution to design AAV capsids with tailored properties, demonstrating improved targeting and tropism in mice.

Cell Press Blue · May 1, 2026Peer-reviewedBioengineering

Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy

Binjie Guo, Hanyu Zheng, Haohan Jiang, Xiaodan Li, Naiyu Guan, Yanming Zuo, Yicheng Zhang, Hengfu Yang, Xuhua Wang

This paper introduces FeatNN, a coevolutionary strategy for predicting compound-protein binding affinity by jointly representing protein sequence and structure information, achieving higher accuracy than existing methods.

Briefings in Bioinformatics · Dec 26, 2022Peer-reviewedBioinformatics