ImmunologybioRxivPreprint
Enhancing anti-gastrointestinal cancer activities of CLDN18.2 CAR-T armored with novel synthetic NKG2D receptors Containing DAP10 and DAP12 signaling domains.
Minmin Sun, Hongye Wang, Ruidong Hao…·Yuanguo Cheng
This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.
DOI 10.1101/2023.05.17.541124