Targeting glucocorticoid signalling in dendritic cells for glioblastoma treatment
Qiuchen Zhao, Jhuma Pramanik, Arif Jabbar, Yifan Gui, Soura Chakraborty, Emily Fysh, Subhanita Ghosh, Pilar Puerto‐Camacho, Miguel Santos, Aws Al-Deka, Matthaios Pitoulias, Hosni Hussein, Christopher J. Ward, George Gentsch, Natalie Z. M. Homer, , Bidesh Mahata
This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.
bioRxiv · Aug 12, 2026 · PreprintImmunology