Bidesh Mahata

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

This study identifies GR-RUNX cooperation in driving CD8 T cell dysfunction in human cancer through transcriptional and chromatin analyses.

This study maps immune cell dynamics during human sequential lymph node metastasis using multi-omics approaches and identifies immune alterations linked to patient survival.

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.

This study shows that immune cell steroidogenesis is essential for resolving inflammation and promoting recovery in acute lung injury.

The paper identifies Posaconazole as a CYP11A1 inhibitor that enhances anti-tumour immunity in a mouse model of lung metastasis.

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

This study uses multiomic methods to identify immunometabolic pathways and drug targets in AMD, highlighting key genes and pathways involved in disease progression and potential therapeutic interventions.

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.