Jhuma Pramanik

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

This study identifies GR-RUNX cooperation in driving CD8 T cell dysfunction in human cancer through transcriptional and chromatin analyses.

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.

This study shows that immune cell steroidogenesis is essential for resolving inflammation and promoting recovery in acute lung injury.

The paper identifies Posaconazole as a CYP11A1 inhibitor that enhances anti-tumour immunity in a mouse model of lung metastasis.

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

The paper uses CRISPR screens in T helper cells to identify genes involved in Th2 differentiation and activation, revealing cross-talk between these processes.