Soura Chakraborty

A cell-intrinsic steroidogenic checkpoint constrains female Th2 effector output independently of gonadal hormones

Targeting glucocorticoid signalling in dendritic cells for glioblastoma treatment

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer

This study identifies GR-RUNX cooperation in driving CD8 T cell dysfunction in human cancer through transcriptional and chromatin analyses.

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

Local glucocorticoid signalling promotes pancreatic cancer

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.

Immune cell de novo steroidogenesis regulates inflammation resolution and recovery in acute lung injury

This study shows that immune cell steroidogenesis is essential for resolving inflammation and promoting recovery in acute lung injury.

Primitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

COVID-19 ORF3a Viroporin Influenced Common and Unique Cellular Signalling Cascades in Lung, Heart and Brain Choroid Plexus Organoids with Additional Enriched MicroRNA Network Analyses for Lung and Brain Tissues

The paper identifies tissue-specific host proteins and miRNA networks influenced by SARS-CoV-2 ORF3a in lung, heart, and brain, suggesting potential drug targets.