PARP1 Regulates 3D Structure and Function of Super-Enhancers and Hormone-Control Regions in Breast Cancer Cells
Houda Baccara, François Le Dily, Davide Carnevali, Jofre Font-Mateu, Cristina Moreta-Moraleda, Alex Franco Galvez, José Carbonell-Caballero, Martin Teichmann, Miguel Beato, Roni H. G. Wright, Roberto Ferrari
This paper shows PARP1 regulates 3D chromatin structure and gene expression at super-enhancers and hormone-control regions in breast cancer cells through chromatin looping and compartment organization.
bioRxiv · Aug 1, 2025 · PreprintGenomics