Miguel Beato

This paper shows PARP1 regulates 3D chromatin structure and gene expression at super-enhancers and hormone-control regions in breast cancer cells through chromatin looping and compartment organization.

The paper shows a progesterone derivative covalently bound to a phospholipid activates breast cancer cell signaling and gene regulation without entering the cell.

This study shows that 3D culture of breast cancer cells alters chromatin structure and gene expression, with LATS1 kinase playing a key role in CTCF displacement and hormonal response.

The paper develops a method to quantify morphological changes during in vitro decidualization using circularity analysis and a statistical model to compare hormonal effects.

This study maps the dynamic signalling network in breast cancer cells responding to progesterone using antibody microarrays and phosphoproteomics, revealing new proteins and pathway connections.

The paper shows TFIIIC binding to Alu elements regulates gene expression through chromatin looping and histone acetylation during serum starvation.

The paper identifies Hormone-Control Regions (HCRs) that organize genome structure and mediate opposing transcriptional responses to steroid hormones in breast cancer cells.

The paper shows that the unliganded progesterone receptor (PR) maintains ESR1 expression and DNA methylation in hormone-deprived breast cancer cells, and that PR depletion leads to increased promoter methylation and reduced ESR1 expression.

OneD improves Hi-C reproducibility for samples with abnormal karyotypes by addressing copy number variations, outperforming existing methods while maintaining performance on normal karyotypes.

The paper shows transcription factors drive genome topology changes before gene expression during cell reprogramming.

The paper compares two Hi-C samples, showing how adherence to FAIR principles leads to successful sequencing projects.

HiC-inspector provides a toolkit for analyzing and visualizing HiC data, including data formatting, alignment, quality control, interaction identification, and interactive visualization.

The paper shows that nuclear ATP, generated from ADP-ribose via NUDIX5/NUDT5, is essential for hormone-induced chromatin remodeling, gene regulation, and cell proliferation.

The paper examines how hormone-induced changes in gene regulation are coordinated by structural transitions of chromatin topological domains in breast cancer cells.