Roni H. G. Wright

This study identifies PARG as a therapeutic target in colorectal cancer, showing that its inhibition synergizes with 5FU and irinotecan to improve treatment efficacy.

This paper shows PARP1 regulates 3D chromatin structure and gene expression at super-enhancers and hormone-control regions in breast cancer cells through chromatin looping and compartment organization.

The paper shows a progesterone derivative covalently bound to a phospholipid activates breast cancer cell signaling and gene regulation without entering the cell.

This study maps the dynamic signalling network in breast cancer cells responding to progesterone using antibody microarrays and phosphoproteomics, revealing new proteins and pathway connections.

The paper identifies Hormone-Control Regions (HCRs) that organize genome structure and mediate opposing transcriptional responses to steroid hormones in breast cancer cells.

The paper shows that the unliganded progesterone receptor (PR) maintains ESR1 expression and DNA methylation in hormone-deprived breast cancer cells, and that PR depletion leads to increased promoter methylation and reduced ESR1 expression.

The paper shows that nuclear ATP, generated from ADP-ribose via NUDIX5/NUDT5, is essential for hormone-induced chromatin remodeling, gene regulation, and cell proliferation.

The paper examines how hormone-induced changes in gene regulation are coordinated by structural transitions of chromatin topological domains in breast cancer cells.