Roberto Ferrari

Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolism

The paper identifies human ASPDH as a 2-aminomuconate reductase in tryptophan catabolism, revealing a new branch of the kynurenine pathway and an unknown amino acid.

PARP1 Regulates 3D Structure and Function of Super-Enhancers and Hormone-Control Regions in Breast Cancer Cells

This paper shows PARP1 regulates 3D chromatin structure and gene expression at super-enhancers and hormone-control regions in breast cancer cells through chromatin looping and compartment organization.

The Multi-State Epigenetic Pacemaker enables the identification of combinations of factors that influence DNA methylation

The paper introduces MSEPM, a multidimensional model for DNA methylation that accounts for age, sex, and cell type, revealing site-specific methylation dynamics influenced by transcription factors.

A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane

The paper shows a progesterone derivative covalently bound to a phospholipid activates breast cancer cell signaling and gene regulation without entering the cell.

The Hippo kinase LATS1 controls CTCF chromatin occupancy and the hormonal response of three-dimensionally grown breast cancer cells

This study shows that 3D culture of breast cancer cells alters chromatin structure and gene expression, with LATS1 kinase playing a key role in CTCF displacement and hormonal response.

Loss of the DYRK1A protein kinase results in reduction of ribosomal protein genes expression, ribosome mass and translation defects

This study shows that DYRK1A regulates ribosomal protein gene expression, ribosome mass, and translation in mammals by interacting with promoters and affecting transcription factor binding.

TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation

The paper shows TFIIIC binding to Alu elements regulates gene expression through chromatin looping and histone acetylation during serum starvation.

Hormone Control Regions mediate opposing steroid receptor-dependent genome organizations

The paper identifies Hormone-Control Regions (HCRs) that organize genome structure and mediate opposing transcriptional responses to steroid hormones in breast cancer cells.