Author

Houssein Fazelinia

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Lynn A. SpruceiD· 2 shared Amita SehgaliD· 1 shared Charalampos PapachristouiD· 1 shared Elizabeth M Brown· 1 shared Erick Astacio· 1 shared Erik Nash· 1 shared Gregory R. GrantiD· 1 shared Joseph A. Stucynski· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Lynn A. SpruceORCID

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2 papers

Recent·Most cited

Gut-derived serine protease reduces sleep but extends lifespan

Rebecca S. Moore, Richard Xiong, Erick Astacio, Julie A. Williams, Thomas G. Brooks, Gregory R. Grant, Joseph A. Stucynski, Houssein Fazelinia, Erik Nash, Lynn A. Spruce, Amita Sehgal

This study identifies a gut-derived serine protease that reduces sleep but extends lifespan in Drosophila by increasing peripheral ROS, suggesting a link between sleep reduction and stress adaptation.

bioRxiv · Jun 29, 2026 · PreprintGenetics

Short-Term Combined Tat-Beclin1 and Endurance Training Improves Age-Related Decline in Physical Function in Male Mice

Thuan Thien Tchen, Shakibur Rahman, Thaysa Ghiarone, Lynn A. Spruce, Houssein Fazelinia, Elizabeth M Brown, Charalampos Papachristou, Sue C. Bodine, Vitor Agnew Lira, Kleiton Augusto Santos Silva

This study combines Tat-Beclin1 and endurance training in old male mice, showing improved physical function compared to either treatment alone.

bioRxiv · May 12, 2026 · PreprintPhysiology