Engineered resistance to Zika virus in transgenic Ae. aegypti expressing a polycistronic cluster of synthetic miRNAs
Anna B. Buchman, Stephanie Gamez, Ming Li, Igor A. Antoshechkin, Hsing-Han Li, Hsin‐Wei Wang, Chun‐Hong Chen, Melissa J. Klein, Jean‐Bernard Duchemin, Prasad N. Paradkar, Omar S. Akbari
This study generates Ae. aegypti mosquitoes engineered with synthetic miRNAs to reduce ZIKV infection, dissemination, and transmission.
Proceedings of the National Academy of Sciences · Feb 5, 2019Peer-reviewedSynthetic Biology