Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons.
Parnika S. Kadam, Zijian Yang, Youtao Lu, Hua Zhu, Yasemin Atiyas, Nishal Shah, Stephen A. Fisher, Erik C. Nordgren, Junhyong Kim, David Issadore, James H. Eberwine
The paper analyzes mtDNA SNVs in single mitochondria from mouse neurons and astrocytes, revealing cell-type-specific mutation patterns and purifying selection.
BMC Biology · Jul 29, 2024Peer-reviewedNeuroscience