Airway applied IVT mRNA vaccine needs specific sequence design and high standard purification that removes devastating dsRNA contaminant
Jingjing Zhang, Chao Li, Yuheng Liu, Rui Liao, Dian He, Lifeng Xu, Tingting Chen, Qin Xiao, Mingxing Luo, Yang Chen, Yali Li, Huaxing Zhu, Joseph Rosenecker, Xiaoyan Ding, Shuchen Pei, Shan Guan
This study shows airway mRNA vaccines need better purification and sequence design to avoid dsRNA contaminants, leading to improved immune responses.
bioRxiv · Sep 22, 2024 · PreprintSynthetic Biology