Mingxing Luo

Host Microenvironment Reprogramming by Saccharides Overcomes Lung Barriers for mRNA Therapeutics

This paper identifies glucose as a reprogramming agent for the airway microenvironment to enhance mRNA delivery and efficacy in lung models.

Airway applied IVT mRNA vaccine needs specific sequence design and high standard purification that removes devastating dsRNA contaminant

This study shows airway mRNA vaccines need better purification and sequence design to avoid dsRNA contaminants, leading to improved immune responses.