Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance
Jianyong Liu, Qing-Li He, Jianya Zhou, Ajay M. Vaghasia, Roshan V. Chikarmane, Glenn Hauk, Archana Rachakonda, Nicole Castagna, Ruchama Chaya Steinberg, Minh‐Tam Pham, Jordan M. Gregg, Alok Mishra, Yuhan Yang, Talha Anwar, Roy Elias, , Srinivasan Yegnasubramanian
This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.
Nature Communications · Aug 26, 2026Peer-reviewedCancer Biology