Prophylactic Lipoxin A4 Attenuates Clostridioides difficile Infection by Augmenting Epithelial Barrier and Resolving Inflammation
Hui Wen, Yunqing Xiang, Yue Yu, Zhixin Ma, Ying Xin, Yufang Deng, Huipai Peng, Yong Shi, Nan Li, Shuqiang Huang
This study shows that prophylactic Lipoxin A4 reduces Clostridioides difficile infection by improving epithelial barrier function and reducing inflammation in both in vitro and mouse models.
bioRxiv · Feb 5, 2026 · PreprintBioengineering