Fan Jin

This study investigates the role of PilU in Pseudomonas aeruginosa surface behaviors by comparing wild-type and ΔpilU mutants, revealing altered twitching motility and colony formation.

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

This paper introduces a high-throughput microscopy platform for screening genetic elements, identifying robust promoters and enabling single-cell phenotyping.

This paper develops a genetic circuit to program bacterial lifestyles in cancer therapy using NIR light, improving therapeutic efficacy through precise control of bacterial behavior.

This paper introduces an optogenetic system to control bacterial pathogenicity in specific host tissues by engineering the Gac/Rsm signaling cascade in Pseudomonas aeruginosa.

This study develops ATI, a method to control biofilm formation in Pseudomonas aeruginosa by manipulating single-cell behaviors through optogenetics and tracking.