Development of a replication-defective MPXV platform for fundamental and therapeutic research
Jiannan Chen, Linyong Hu, Ning Shi, J.H. Tian, Yuyi Zhang, Sicheng Tian, Xinyu Cao, Zhuo Ha, Qiliang Cai, Yongxu Lu, Geoffrey L. Smith, Youhua Xie, Huijun Lu, Ping Zhang, Rong Zhang
This paper develops a replication-defective MPXV platform for antiviral research and virology studies by engineering particles that recapitulate key viral life cycle stages without requiring high-containment facilities.
bioRxiv · Jun 21, 2025 · PreprintMicrobiology