Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates
Valentina Davì, Pierre Parutto, Cécile C. Crapart, Yuyi Zhang, Tasuku Konno, Joseph E. Chambers, John P Franklin, Daniel C. Maddison, Mosab Ali Awadelkareem, Michael J. Devine, Elena F. Koslover, Edward Avezov
The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.
bioRxiv · Oct 6, 2025 · PreprintCell Biology