Native CRISPR-Cas mediated in situ genome editing reveals the exquisite interplay of resistance mutations in clinical multidrug resistant Pseudomonas aeruginosa
Zeling Xu, Ming Li, Yanran Li, Huiluo Cao, Patrick CY Woo, Hua Xiang, Aixin Yan
This study uses native CRISPR-Cas genome editing to analyze resistance mechanisms in a multidrug-resistant Pseudomonas aeruginosa strain, revealing synergistic effects between efflux pumps and target mutations.
bioRxiv · Jan 8, 2019 · PreprintMicrobiology