Hua Xiang

This paper develops a compact type I-F2 CRISPR-Cas system for transcriptional activation and base editing in human cells, achieving a wide editing window and high efficiency.

This paper computationally redesigns PETase to improve its stability and PET degradation efficiency using the GRAPE strategy.

This study uses native CRISPR-Cas genome editing to analyze resistance mechanisms in a multidrug-resistant Pseudomonas aeruginosa strain, revealing synergistic effects between efflux pumps and target mutations.