Aixin Yan

This study identifies a Mg-Fe-PmrAB regulatory circuit that mediates polymyxin tolerance in Enterobacteriaceae under phosphate starvation and shows that targeting this circuit can reverse tolerance.

This paper develops a FRET-based assay to monitor TF-promoter interactions in living bacteria and demonstrates its application in identifying modulators and studying bacterial-host interactions.

This study uses native CRISPR-Cas genome editing to analyze resistance mechanisms in a multidrug-resistant Pseudomonas aeruginosa strain, revealing synergistic effects between efflux pumps and target mutations.