MOLECULAR BASIS FOR PINK1 MATURATION
Junrong Xue, Huiqin Xu, Yanfeng Zhang, Xinrong Yu, Yan Du, Jia Guo, Jianing Duan, Weida Zhang, Xujia Liu, Yuanzhu Gao, Shuaijiabin Chen, Sen‐Fang Sui, Xiaohong Qin, Zheng Liu, Li-Zhi Mi
This study identifies the structural basis for PINK1 maturation by the HSP90/CDC37/FKBP51 chaperone complex and shows FKBP51 negatively regulates PINK1 function in mitophagy.
bioRxiv · Aug 23, 2026 · PreprintBiophysics