Fine-mapping of nuclear compartments using ultra-deep Hi-C shows that active promoter and enhancer elements localize in the active A compartment even when adjacent sequences do not
Hannah L. Harris, Huiya Gu, Moshe Olshansky, Ailun Wang, Irene Farabella, Yossi Eliaz, Achyuth Kalluchi, Akshay Krishna, Mozes Jacobs, A. Gesine Cauer, Melanie Pham, Suhas S.P. Rao, Olga Dudchenko, Arina D. Omer, Kiana Mohajeri, , M. Jordan Rowley
The paper uses ultra-deep Hi-C and a new computational method to fine-map nuclear compartments, revealing that active promoters and enhancers localize in the A compartment even when adjacent sequences are inactive.
Nature Communications · Jun 6, 2023Peer-reviewedGenomics