Matt Kanke

This study identifies Homer1 as a gene that modulates attention by altering prefrontal cortex inhibitory tone and signal-to-noise ratio in mice.

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

This study investigates immune regulation in symbiotic and aposymbiotic coral tissue using multiomic approaches, revealing compartmentalized immune suppression in specific cell types during symbiosis.

The paper identifies post-transcriptional regulators in early human small intestinal development using multi-omic analyses and presents a web tool for exploring miRNA regulation.

This paper describes a method to efficiently generate definitive hemogenic endothelium from human pluripotent stem cells, which can differentiate into hematopoietic progenitors and stem cells with multilineage potential.

The paper uses single-cell analysis to compare colonic epithelial cells in Crohn's disease and control patients, revealing shifts in cell composition and gene expression patterns.

This study identifies miR-375 as a key regulator of intestinal crypt homeostasis, showing its role in stem cell proliferation, tuft cell abundance, and resistance to infection and cancer.

The paper provides multi-genomic maps of the EndoC-βH1 cell model to define gene regulatory programs in human pancreatic β cells and identifies allelic effects on cis-regulatory elements.