Achyuth Kalluchi

This study identifies ECD's RNA-binding activity and shows it stabilizes U5 snRNP and is essential for pre-mRNA splicing.

The paper introduces CRUSH, a method to refine chromatin compartments to 1 kb resolution, revealing regulatory programs across cell types and a woolly mammoth's cold-adapted regulome.

HiCrayon co-visualizes 3D chromatin conformation with 1D genomic data to reveal new insights into chromatin organization.

This paper reports the 3D genome architecture of a 52,000-year-old woolly mammoth using a novel method, revealing conserved epigenetic features across elephantids.

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

The paper uses ultra-deep Hi-C and a new computational method to fine-map nuclear compartments, revealing that active promoters and enhancers localize in the A compartment even when adjacent sequences are inactive.

This study examines 3D genome dynamics in mouse brain neurons across the estrous cycle and by sex, finding cycle-driven changes and estrogen-related similarities to male genomes.