Astrocytes mediate the pro-cognitive value of α7nAChRs and of α7nAChR-targeting therapeutics
Yifan Wu, Michaela Tolman, Yanchao Dai, Sarah Walsh, Humza Agha, Katheryn B. Lefton, Hannah An, Rachel Manno, Philip G. Haydon, Thomas Papouin
This study identifies astrocytes and D-serine/NMDAR signaling as key mediators of the cognitive benefits of α7nAChRs and their targeting therapeutics in mice.
bioRxiv · Apr 19, 2026 · PreprintNeuroscience