Yanchao Dai

This study identifies astrocytes and D-serine/NMDAR signaling as key mediators of the cognitive benefits of α7nAChRs and their targeting therapeutics in mice.

This study shows that ventral striatal astrocytes influence reinforcement learning by modulating decision noisiness and reward-guided choice through calcium dynamics.

This study shows that norepinephrine modulates synapses via astrocytic adrenergic receptors and Ca2+ dynamics, independent of neuronal receptors.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

STARDUST is a pipeline that analyzes astrocyte calcium dynamics by detecting and extracting discrete calcium signals from fluorescence recordings.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

The paper identifies hypothalamic gene network dysfunction in AD mice, linking it to cognitive decline and body weight loss through RNA sequencing and network analysis.