Efficient differentiation of human primordial germ cells through geometric control reveals a key role for NODAL signaling
Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R. Spence, Idse Heemskerk
The paper demonstrates that geometric control of human pluripotent stem cells with BMP4 leads to efficient differentiation into hPGC-like cells, revealing NODAL signaling's critical role and improving differentiation efficiency.
eLife · Apr 8, 2022Peer-reviewedDevelopmental Biology