Ran Ran

Personalized Gut-Liver Microphysiological System Maps Donor-Specific Tissue Resident Immunity and Reveals a Conserved Metabolic Crosstalk

The paper builds a personalized gut-liver microphysiological system to study donor-specific immune profiles and reveals a conserved metabolic crosstalk between gut and liver.

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood Axis

The paper tracks T cell clones across gut, liver, and blood using single-cell RNA and TCR sequencing, revealing tissue-specific adaptations and limited overlap between colonic IELs and lamina propria T cells.

Systematic Analysis of Human Colorectal Cancer scRNA-seq Revealed Limited Pro-tumoral IL-17 Production Potential in Gamma Delta T Cells

This study analyzes scRNA-seq data from human colorectal cancer to show that gamma delta T cells do not produce pro-tumoral IL-17, functioning mainly as cytotoxic effector cells.

Enhanced Annotation of CD45RA to Distinguish T cell Subsets in Single Cell RNA-seq via Machine Learning

The paper develops a machine learning classifier to infer CD45RA levels from scRNA-seq data, improving T cell subset annotation with high accuracy.

Efficient differentiation of human primordial germ cells through geometric control reveals a key role for NODAL signaling

The paper demonstrates that geometric control of human pluripotent stem cells with BMP4 leads to efficient differentiation into hPGC-like cells, revealing NODAL signaling's critical role and improving differentiation efficiency.

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling

This study identifies GAS5 as a regulator of TGF-β-induced fibroblast activation by inhibiting Smad3 signaling, showing therapeutic potential for fibrotic diseases.