Author

Emily Freeburne

University of MichiganORCID 0000-0003-0344-577XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Idse HeemskerkiD· 4 shared Bohan CheniD· 3 shared Craig N. JohnsoniD· 3 shared Hina Aftab KhaniD· 3 shared Kyoung JoiD· 3 shared Seth TeagueiD· 3 shared Abdul-Bassit Fijabi· 1 shared Bolin LiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersDevelopmental Biology

Idse HeemskerkORCID

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4 papers

Recent·Most cited

Interpretable decoding of cell fate from a snapshot of combinatorial signaling

Abdul-Bassit Fijabi, Seth Teague, Emily Freeburne, Hina Aftab Khan, Craig N. Johnson, David B. Brückner, Idse Heemskerk

The paper shows that a single snapshot of combinatorial signaling can predict cell fate in human embryonic patterning using Sig2Fate, a method combining immunofluorescence, information theory, and machine learning.

bioRxiv · May 18, 2026 · PreprintDevelopmental Biology

Extended culture of 2D gastruloids to model human mesoderm development

Bohan Chen, Hina Khan, Zhiyuan Yu, LiAng Yao, Emily Freeburne, Kyoung Jo, Craig N. Johnson, Idse Heemskerk

The paper extends the culture of 2D gastruloids to 96h, revealing a phase of mesoderm differentiation with spatial organization similar to embryos.

Nature Methods · May 7, 2025Peer-reviewedDevelopmental Biology

The time integral of BMP signaling determines fate in a stem cell model for early human development

Seth Teague, Gillian Primavera, Bohan Chen, Emily Freeburne, Hina Aftab Khan, Kyoung Jo, Craig N. Johnson, Idse Heemskerk

The paper shows that the time integral of BMP signaling determines cell fate in human pluripotent stem cells, with duration and level of signaling being interchangeable in this context.

bioRxiv · Apr 10, 2023 · PreprintDevelopmental Biology

Efficient differentiation of human primordial germ cells through geometric control reveals a key role for NODAL signaling

Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R. Spence, Idse Heemskerk

The paper demonstrates that geometric control of human pluripotent stem cells with BMP4 leads to efficient differentiation into hPGC-like cells, revealing NODAL signaling's critical role and improving differentiation efficiency.

eLife · Apr 8, 2022Peer-reviewedDevelopmental Biology