RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation
I-Hui Wu, Xi Wang, Ryan Clark, Soroor Farahnak, Sadeem Ahmad, Sun Hur
The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.
bioRxiv · May 29, 2026 · PreprintMolecular Biology