Sun Hur

This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.

The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.

The paper shows FoxP3 forms head-to-head dimers and stabilizes multimerization on microsatellites in Tregs, revealing a dual DNA-binding mode.

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

This study shows FoxP3 forms different supramolecular structures on microsatellites, enabling it to bridge DNA duplexes and coordinate genomic loci, with nucleosomes aiding assembly.

This paper identifies a mechanism by which T7 RNA polymerase generates immune-stimulatory dsRNA through promoter-independent transcription, and shows how this activity can be controlled.