Author

Sadeem Ahmad

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Sun HuriD· 3 shared Aaron Orgel· 1 shared Alyssa R. Fishbein· 1 shared Anton Davydenko· 1 shared Diego Capcha-RodrigueziD· 1 shared Emily GreenwaldiD· 1 shared Erez Y. LevanoniD· 1 shared I-Hui Wu· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Sun HurORCID

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3 papers

Recent·Most cited

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation

I-Hui Wu, Xi Wang, Ryan Clark, Soroor Farahnak, Sadeem Ahmad, Sun Hur

The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.

bioRxiv · May 29, 2026 · PreprintMolecular Biology

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Jeiwen Chou, Matthew M. Meyerson, Sun Hur

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

Nature Communications · Apr 8, 2025Peer-reviewedBiochemistry

An origin of the immunogenicity of in vitro transcribed RNA

Xin Ni Mu, Emily Greenwald, Sadeem Ahmad, Sun Hur

This paper identifies a mechanism by which T7 RNA polymerase generates immune-stimulatory dsRNA through promoter-independent transcription, and shows how this activity can be controlled.

Nucleic Acids Research · Feb 28, 2018Peer-reviewedMolecular Biology