Ryan Clark

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation

The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.

FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites

The paper shows FoxP3 forms head-to-head dimers and stabilizes multimerization on microsatellites in Tregs, revealing a dual DNA-binding mode.