CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3
J. T. Cortez, E. Montauti, E. Shifrut, Y. Zhang, O. Shaked, Y. Xu, T. Roth, D. Simeonov, Y. Zhang, S. Chen, Z. Li, I. A. Vogel, G. Y. Prator, B. Zhang, Y. Lee, , D. Fang
This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.
bioRxiv · Feb 26, 2020 · PreprintImmunology