Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis
D. Kim, G. Kim, R. Yu, J. Lee, S. Kim, K. Qiu, E. Montauti, D. Fang, N. S. Chandel, J. Choi, B. Min
This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.
bioRxiv · Feb 13, 2023 · PreprintImmunology