NLRP3- and AIM2-autonomy in a mouse model of MSU crystal-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1 expression as relevant therapy for gout patients.
A. Mariotte, A. Decauwer, C. Po, C. Abou-Faycal, A. Pichot, N. Paul, I. Aouadi, R. Carapito, B. Frisch, C. Macquin, E. Chatelus, J. Sibilia, J.-P. Armspach, S. Bahram, P. Georgel
This study uses a mouse model to investigate MSU crystal-induced inflammation and identifies imiquimod as a potential therapeutic target for gout by modulating IL-1 expression.
bioRxiv · Jan 28, 2020 · PreprintImmunology