N. Paul

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

This study investigates how pH affects the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes, identifying a protonable group influencing its reduction potential.

Primary production dynamics during the decline phase of the North Atlantic annual spring bloom

This study examines primary production dynamics during the decline phase of the North Atlantic spring bloom, showing variability in phytoplankton size fractions and the impact of physical disturbances on production rates.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration

This study identifies CYRI-A as a regulator of macropinocytic cup maturation and integrin uptake, showing its role in limiting invasive migration.

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

NLRP3- and AIM2-autonomy in a mouse model of MSU crystal-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1 expression as relevant therapy for gout patients.

This study uses a mouse model to investigate MSU crystal-induced inflammation and identifies imiquimod as a potential therapeutic target for gout by modulating IL-1 expression.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.