R. Carapito

Endothelial calcium firing mediates extravasation of metastatic tumor cells.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.

Peripheral positioning of lysosomes supports melanoma aggressiveness

This study shows that lysosomal positioning in melanoma cells correlates with aggressiveness, promoting invasion and matrix degradation.

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis

This study shows that blood flow enhances the pro-angiogenic effects of tumor-derived extracellular vesicles by altering their intracellular trafficking in endothelial cells.

Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism

This study shows that autophagy regulates lipid metabolism in Langerhans cells, preventing their depletion and ferroptosis in the epidermis.

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

NLRP3- and AIM2-autonomy in a mouse model of MSU crystal-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1 expression as relevant therapy for gout patients.

This study uses a mouse model to investigate MSU crystal-induced inflammation and identifies imiquimod as a potential therapeutic target for gout by modulating IL-1 expression.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.