Author

I. Astapova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Sargsyan· 3 shared M. A. Herman· 3 shared S. A. Hannou· 3 shared W. Tong· 3 shared G.-F. Zhang· 2 shared P. A. Grimsrud· 2 shared R. Monn· 2 shared D. Li· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPhysiology

A. Sargsyan

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Author profile →

3 papers

Recent·Most cited

Metformin Impairs Intestinal Fructose Metabolism

W. Tong, S. A. Hannou, A. Sargsyan, G.-F. Zhang, P. A. Grimsrud, I. Astapova, M. A. Herman

This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.

bioRxiv · Apr 17, 2023 · PreprintPhysiology

The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice

W. Tong, S. A. Hannou, Y. Wang, I. Astapova, A. Sargsyan, R. Monn, V. Thiriveedi, D. Li, J. R. McCann, J. F. Rawls, J. Roper, G.-F. Zhang, M. A. Herman

This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.

bioRxiv · Jan 20, 2022Physiology

HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis

A. Sargsyan, L. Doridot, S. A. Hannou, W. Tong, H. Srinivasan, R. Ivison, R. Monn, H. H. Kou, J. M. Haldeman, M. Arlotto, P. J. White, P. A. Grimsrud, I. Astapova, L. Tsai, M. A. Herman

The paper identifies HGFAC as a ChREBP-regulated hepatokine that improves glucose and lipid homeostasis through activation of PPARγ in mice.

bioRxiv · Jul 29, 2021Physiology