Author

D. K. Crossman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. L. Alexander· 2 shared L. E. Smythies· 2 shared M. R. Crowley· 2 shared P. D. Smith· 2 shared A. Chakraborty· 1 shared A. D. Robinson· 1 shared A. K. Bajpai· 1 shared A. L. Longhini· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

K. L. Alexander

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Novel Biomarkers and Distinct Transcriptomic Profile of Barrett's Esophagus Epithelial Stem Cells

K. L. Alexander, L. E. Smythies, K. R. Kyanam-Kabir-Baig, E. Poovey, D. K. Crossman, P. D. Smith, S. Peter

The paper identifies novel biomarkers and transcriptomic profiles in Barrett's esophagus epithelial stem cells, highlighting CT83 and ST6GAL1 as potential indicators for cancer progression.

bioRxiv · Aug 7, 2023 · PreprintCancer Biology

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

A. Chakraborty, N. Bhalerao, M. P. Marciel, J. Hwang, C. Britain, E. E. Eltoum, R. B. Jones, K. L. Alexander, L. E. Smythies, P. D. Smith, D. K. Crossman, M. R. Crowley, B. Shin, L. E. Harrington, Z. Yan, , S. L. Bellis

This study identifies ST6GAL1 sialyltransferase as a promoter of acinar-to-ductal metaplasia and pancreatic cancer progression through glycosylation-dependent mechanisms.

bioRxiv · Apr 28, 2022 · PreprintCancer Biology

Natural isolate and recombinant SARS-CoV-2 rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage

N. Shiliaev, T. Lukash, O. Palchevska, D. K. Crossman, T. J. Green, M. Crowley, E. I. Frolova, I. Frolov

This study shows that SARS-CoV-2 rapidly evolves in vitro to bind heparan sulfate more efficiently and reduce S1/S2 cleavage, increasing infectivity and decreasing GE:PFU ratios.

bioRxiv · Jun 28, 2021Microbiology

Selective LXR agonist, DMHCA, corrects the retina-bone marrow axis in type 2 diabetes

C. P. Vieira, S. D. Fortmann, M. Hossain, A. L. Longhini, S. S. Hammer, B. Asare-Bediako, D. K. Crossman, M. S. Sielski, Y. Adu-Agyeiwaah, M. Dupont, J. L. Floyd, S. Li Calzi, T. Lydic, R. S. Welner, G. J. Blanchard, , M. B. Grant

This study shows that DMHCA, a selective LXR agonist, corrects the retina-bone marrow axis in type 2 diabetes by restoring retinal function, cholesterol homeostasis, and hematopoietic stem cell balance.

bioRxiv · Feb 11, 2020 · PreprintCell Biology

Therapeutically actionable PAK4 is amplified, overexpressed and involved in bladder cancer progression

D. S. Chandrashekar, B. V. S. K. Chakravarthi, A. D. Robinson, J. C. Anderson, S. Agarwal, S. A. Hodigere Balasubramanya, M.-L. Eich, A. K. Bajpai, S. Davuluri, M. S. Guru, A. S. Guru, G. Naik, D. L. Della Manna, K. K. Acharya, S. Carskadon, , S. Varambally

This study identifies PAK4 amplification and overexpression in bladder cancer and shows PAK4 inhibition reduces tumor growth, with potential for combination therapy.

bioRxiv · Aug 20, 2019Cancer Biology

Fc receptor-like 6 (FCRL6) defines pre-BCR dependent and independent pathways of natural antibody selection

R. S. Davis, K. Honjo, W.-J. Won, R. G. King, L. Ianov, D. K. Crossman, J. L. Easlick, M. A. Shakhmatov, M. Khass, A. M. Vale, R. P. Stephan, R. Li

This study identifies FCRL6-expressing B cell progenitors that influence natural antibody selection through distinct pre-BCR dependent and independent pathways.

bioRxiv · Jun 11, 2019 · PreprintImmunology