I. Gallego

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

The paper determines the cryo-EM structure of a triplet polymerase ribozyme and maps its functional landscape using mutation analysis.

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

This study shows that guanosine inhibits HCV replication by altering intracellular nucleotide pools, leading to increased indels and reduced viral infectivity.

SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease Outcome

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

A two-level, dynamic fitness landscape of hepatitis C virus revealed by self-organized haplotype maps

This study constructs a dynamic two-layer fitness landscape of HCV using self-organized haplotype maps from deep sequencing data during adaptation in cell culture.

Amino acid substitutions associated with treatment failure of hepatitis C virus infection

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

Dissimilar conservation pattern in hepatitis C virus mutant spectra, consensus sequences, and data banks

The paper examines conservation patterns in HCV mutant spectra, consensus sequences, and data banks, finding mismatches that challenge assumptions about sequence conservation for vaccine design.