Author

E. K. S. McRae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

E. S. Andersen· 4 shared C. Geary· 2 shared A. Boussebayle· 1 shared B. K. Hansen· 1 shared C. J. K. Wan· 1 shared E. Gianni· 1 shared E. L. Kristoffersen· 1 shared E. P. Booy· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

E. S. Andersen

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5 papers

Recent·Most cited

Tertiary structure of single-instant RNA molecule reveals folding landscape

J. Liu, E. K. S. McRae, C. Geary, E. S. Andersen, G. Ren

The paper uses cryo-electron tomography to study the folding landscape of an RNA origami 6-helix bundle, revealing multiple conformations and a possible folding pathway.

bioRxiv · May 19, 2023 · PreprintBiochemistry

An RNA origami robot that traps and releases a fluorescent aptamer

N. Sampedro Vallina, E. K. S. McRae, C. Geary, E. S. Andersen

This paper introduces an RNA origami robot called Traptamer that senses RNA strands, acts as a Boolean AND gate, and releases a fluorescent aptamer through mechanical reconfiguration.

bioRxiv · May 19, 2023 · PreprintBioengineering

RNA origami scaffolds as a cryo-EM tool for investigating aptamer-ligand binding of a Broccoli-Pepper FRET pair

N. S. Vallina, E. K. S. McRae, B. K. Hansen, A. Boussebayle, E. S. Andersen

This study uses RNA origami scaffolds to enhance cryo-EM resolution of small aptamer-ligand complexes, revealing precise conformational changes in a Broccoli-Pepper FRET pair.

bioRxiv · Aug 25, 2022 · PreprintBiochemistry

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

E. K. S. McRae, C. J. K. Wan, E. L. Kristoffersen, K. Hansen, E. Gianni, I. Gallego, J. F. Curran, J. Attwater, P. Holliger, E. S. Andersen

The paper determines the cryo-EM structure of a triplet polymerase ribozyme and maps its functional landscape using mutation analysis.

bioRxiv · Aug 23, 2022Biochemistry

An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21

E. K. S. McRae, S. J. Dupas, E. P. Booy, R. S. Piragasam, R. P. Fahlman, S. A. McKenna

This study identifies DDX21's role in regulating MAGED2 protein levels via RNA G-quadruplexes, leading to TRAIL-R2 upregulation and apoptosis sensitivity.

bioRxiv · Mar 26, 2019Biochemistry