The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs
L. Gaucherand, A. Iyer, I. Gilabert, C. H. Rycroft, M. M. Gaglia
The paper identifies GCUG tetramers in hairpin loops as PA-X cleavage sites, showing PA-X discriminates host from viral mRNAs by targeting GCUG-rich regions prevalent in host transcripts.
bioRxiv · Jul 8, 2022Microbiology