Author

C. H. Rycroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Gaucherand· 2 shared A. Amir· 1 shared A. Iyer· 1 shared A. N. Septer· 1 shared B. K. Porter· 1 shared C. McCormick· 1 shared D. A. Khaperskyy· 1 shared E. Kanso· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

L. Gaucherand

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Author profile →

4 papers

Recent·Most cited

How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution

N. M. Boffi, Y. Guo, C. H. Rycroft, A. Amir

This study uses a computational model to show how microscopic epistasis and clonal interference affect microbial fitness trajectories, finding that epistasis slows growth while clonal interference speeds it up under certain conditions.

bioRxiv · Jan 16, 2023Evolutionary Biology

The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs

L. Gaucherand, A. Iyer, I. Gilabert, C. H. Rycroft, M. M. Gaglia

The paper identifies GCUG tetramers in hairpin loops as PA-X cleavage sites, showing PA-X discriminates host from viral mRNAs by targeting GCUG-rich regions prevalent in host transcripts.

bioRxiv · Jul 8, 2022Microbiology

A subcellular biochemical model for T6SS dynamics reveals winning competitive strategies

Y. L. Lin, S. N. Smith, E. Kanso, A. N. Septer, C. H. Rycroft

The paper builds a subcellular biochemical model of T6SS dynamics to identify winning competitive strategies between T6SS-armed and unarmed bacterial populations.

bioRxiv · Jul 17, 2021Microbiology

The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

L. Gaucherand, B. K. Porter, S. K. Schmaling, C. H. Rycroft, Y. Kevorkian, C. McCormick, D. A. Khaperskyy, M. Gaglia

This study identifies PA-X, an influenza A virus protein, as a factor that selectively targets host mRNAs for degradation by hijacking RNA splicing machinery.

bioRxiv · Oct 14, 2018Microbiology